Sigma receptors suppress multiple aspects of microglial activation
نویسندگان
چکیده
منابع مشابه
Afobazole modulates microglial function via activation of both sigma-1 and sigma-2 receptors.
Microglial cells play a critical role in the neuroinflammatory response that accompanies various diseases of the central nervous system, such as ischemic stroke, and ATP is a major signaling molecule regulating the response of these cells to these pathophysiological conditions. Experiments were carried out to determine the effects of afobazole on microglial function and to identify the molecula...
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ژورنال
عنوان ژورنال: Glia
سال: 2009
ISSN: 0894-1491,1098-1136
DOI: 10.1002/glia.20802